Nonlinear activation functions are pivotal to the success of deep neural nets, and choosing the appropriate activation function can significantly affect their performance. Most networks use fixed activation functions (e.g., ReLU, GELU, etc.), which can be sub-optimal as their expressiveness is limited. Furthermore, distinct layers may benefit from diverse activation functions. Consequently, there has been a growing interest in trainable activation functions. In this paper, we introduce DiTAC, a trainable highly-expressive activation function based on an efficient diffeomorphic transformation. Despite introducing only a negligible number of trainable parameters, DiTAC enhances model expressiveness and performance, often yielding substantial improvements. It also outperforms existing activation functions (regardless whether the latter are fixed or trainable) in tasks such as semantic segmentation, image generation, regression problems, and image classification. Our code will be made publicly available upon acceptance.